The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

Gastroesophageal reflux disease (GERD) is now one of the most common diagnoses made
in a gastroenterology practice. From a conventional pathophysiological perspective, GERD …

The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …

Background DNA methylation changes that accrue in the stem cell pool of an adult tissue in
line with the cumulative number of cell divisions may contribute to the observed variation in …

Esophageal cancer (EC) is one of the most lethal cancers and a public health concern
worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous …

DNA methylation clocks can accurately estimate chronological age and, to some extent, also
biological age, yet the process by which age-associated DNA methylation (DNAm) changes …

The early diagnosis and accurate prognosis prediction of esophageal cancer is an essential
part of improving survival. However, these diseases lack effective and specific markers. A …

Esophageal cancer (ESCA) is the seventh most frequent and deadly neoplasm. Due to the
lack of early diagnosis and high invasion/metastasis, the prognosis of ESCA remains very …

The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to
be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) …

Background CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype,
observed in multiple malignancies and associated with the epigenetic silencing of tumor …