Toward a foundation model of causal cell and tissue biology with a Perturbation Cell and Tissue Atlas
JE Rood, A Hupalowska, A Regev - Cell, 2024 - cell.com
Comprehensively charting the biologically causal circuits that govern the phenotypic space
of human cells has often been viewed as an insurmountable challenge. However, in the last …
of human cells has often been viewed as an insurmountable challenge. However, in the last …
Deciphering the impact of genomic variation on function
Code of Conduct Committee (alphabetical by last name … - Nature, 2024 - nature.com
Our genomes influence nearly every aspect of human biology—from molecular and cellular
functions to phenotypes in health and disease. Studying the differences in DNA sequence …
functions to phenotypes in health and disease. Studying the differences in DNA sequence …
Identifying genetic variants that influence the abundance of cell states in single-cell data
Disease risk alleles influence the composition of cells present in the body, but modeling
genetic effects on the cell states revealed by single-cell profiling is difficult because variant …
genetic effects on the cell states revealed by single-cell profiling is difficult because variant …
Robust differential expression testing for single-cell CRISPR screens at low multiplicity of infection
Single-cell CRISPR screens (perturb-seq) link genetic perturbations to phenotypic changes
in individual cells. The most fundamental task in perturb-seq analysis is to test for …
in individual cells. The most fundamental task in perturb-seq analysis is to test for …
Modeling gene interactions in polygenic prediction via geometric deep learning
Polygenic risk score (PRS) is a widely used approach for predicting individuals' genetic risk
of complex diseases, playing a pivotal role in advancing precision medicine. Traditional …
of complex diseases, playing a pivotal role in advancing precision medicine. Traditional …
MorPhiC Consortium: towards functional characterization of all human genes
Recent advances in functional genomics and human cellular models have substantially
enhanced our understanding of the structure and regulation of the human genome …
enhanced our understanding of the structure and regulation of the human genome …
TLNRD1 is a CCM complex component and regulates endothelial barrier integrity
We previously identified talin rod domain-containing protein 1 (TLNRD1) as a potent actin-
bundling protein in vitro. Here, we report that TLNRD1 is expressed in the vasculature in …
bundling protein in vitro. Here, we report that TLNRD1 is expressed in the vasculature in …
Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis
B **a, Y Lu, J Peng, J Liang, F Li, J Ding, C Wan… - Scientific Reports, 2025 - nature.com
DNA methylation modifications are an important mechanism affecting the process of
atherosclerosis (AS). Previous studies have shown that Galectin-8 (GAL8) DNA methylation …
atherosclerosis (AS). Previous studies have shown that Galectin-8 (GAL8) DNA methylation …
Clinical and Genomic Prediction of Coronary Artery Disease Subtypes
BACKGROUND: Coronary artery disease (CAD) is a complex, heterogeneous disease with
distinct etiological mechanisms. These different etiologies may give rise to multiple subtypes …
distinct etiological mechanisms. These different etiologies may give rise to multiple subtypes …
Massively parallel approaches for characterizing noncoding functional variation in human evolution
Highlights●Human evolution/adaptation is substantially driven by noncoding, regulatory
changes.●Novel high-throughput methods can characterize the function of evolutionarily …
changes.●Novel high-throughput methods can characterize the function of evolutionarily …