Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical
signals into biochemical responses, has focused on identification of critical …

Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

Aging listeners experience greater difficulty understanding speech in adverse listening
conditions and exhibit degraded temporal resolution, even when audiometric thresholds are …

Tissue morphogenesis during development is dependent on activities of the cadherin family
of cell–cell adhesion proteins that includes classical cadherins, protocadherins, and atypical …

Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This
progressive hearing impairment leads to social isolation and is also associated with …

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces
regulate a large array of physiological processes, and dysregulation of mechanical …

Hair cells of the inner ear are mechanosensors that transduce mechanical forces arising
from sound waves and head movement into electrochemical signals to provide our sense of …

Of Aristotle's five senses, we know that sight, smell and much of taste are initiated by ligands
binding to G-protein-coupled receptors; however, the mechanical sensations of touch and …

Usher syndrome (USH), clinically and genetically heterogeneous, is the leading genetic
cause of combined hearing and vision loss. USH is classified into three types, based on the …

Mechanical deflection of the sensory hair bundles of receptor cells in the inner ear causes
ion channels located at the tips of the bundle to open, thereby initiating the perception of …