[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
[HTML][HTML] Long non-coding RNA and RNA-binding protein interactions in cancer: experimental and machine learning approaches
Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …
comprise the bulk of the genome, is important for understanding virtually every hallmark of …
Targeting **st with compounds that disrupt RNA structure and X inactivation
Although more than 98% of the human genome is non-coding, nearly all of the drugs on the
market target one of about 700 disease-related proteins. The historical reluctance to invest …
market target one of about 700 disease-related proteins. The historical reluctance to invest …
RNA structure probing uncovers RNA structure-dependent biological functions
RNA molecules fold into complex structures that enable their diverse functions in cells.
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …
Beamline B21: high-throughput small-angle X-ray scattering at Diamond Light Source
B21 is a small-angle X-ray scattering (SAXS) beamline with a bending magnet source in the
3 GeV storage ring at the Diamond Light Source Ltd synchrotron in the UK. The beamline …
3 GeV storage ring at the Diamond Light Source Ltd synchrotron in the UK. The beamline …
From structure to function: Route to understanding lncRNA mechanism
J Graf, M Kretz - BioEssays, 2020 - Wiley Online Library
RNAs have emerged as a major target for diagnostics and therapeutics approaches.
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
Methylation across the central dogma in health and diseases: new therapeutic strategies
R Liu, E Zhao, H Yu, C Yuan, MN Abbas… - Signal Transduction and …, 2023 - nature.com
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
The molecular structure of long non-coding RNAs: emerging patterns and functional implications
Long non-coding RNAs (lncRNAs) are recently-discovered transcripts that regulate vital
cellular processes and are crucially connected to diseases. Despite their unprecedented …
cellular processes and are crucially connected to diseases. Despite their unprecedented …
Mechanism of efficient double-strand break repair by a long non-coding RNA
Mechanistic studies in DNA repair have focused on roles of multi-protein DNA complexes,
so how long non-coding RNAs (lncRNAs) regulate DNA repair is less well understood. Yet …
so how long non-coding RNAs (lncRNAs) regulate DNA repair is less well understood. Yet …
Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery
In recent years, researchers have identified certain RNAs as druggable targets for small
molecules to treat several human pathologies. However, these regulatory RNAs are …
molecules to treat several human pathologies. However, these regulatory RNAs are …