Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Advanced drug delivery systems and artificial skin grafts for skin wound healing

HS Kim, X Sun, JH Lee, HW Kim, X Fu… - Advanced drug delivery …, 2019 - Elsevier
Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require
painstakingly long-term treatment with an immense financial burden to healthcare systems …

[HTML][HTML] Bioactive hydrogels for bone regeneration

X Bai, M Gao, S Syed, J Zhuang, X Xu, XQ Zhang - Bioactive materials, 2018 - Elsevier
Bone self-healing is limited and generally requires external intervention to augment bone
repair and regeneration. While traditional methods for repairing bone defects such as …

Shear-thinning and self-healing hydrogels as injectable therapeutics and for 3D-printing

C Loebel, CB Rodell, MH Chen, JA Burdick - Nature protocols, 2017 - nature.com
The design of injectable hydrogel systems addresses the growing demand for minimally
invasive approaches for local and sustained delivery of therapeutics. We developed a class …

Effects of mesenchymal stem cell‐derived paracrine signals and their delivery strategies

C Chang, J Yan, Z Yao, C Zhang, X Li… - Advanced healthcare …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …

Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration

Y Cao, J Tan, H Zhao, T Deng, Y Hu, J Zeng… - Nature …, 2022 - nature.com
Transplantation of mesenchymal stem cells (MSCs) holds promise to repair severe traumatic
injuries. However, current transplantation practices limit the potential of this technique, either …

A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing

Q Xu, A Sigen, Y Gao, L Guo, J Creagh-Flynn, D Zhou… - Acta biomaterialia, 2018 - Elsevier
The injectable hydrogel with desirable biocompatibility and tunable properties can improve
the efficacy of stem cell-based therapy. However, the development of injectable hydrogel …

Injectable hydrogels for cardiac tissue engineering

B Peña, M Laughter, S Jett, TJ Rowland… - Macromolecular …, 2018 - Wiley Online Library
In light of the limited efficacy of current treatments for cardiac regeneration, tissue
engineering approaches have been explored for their potential to provide mechanical …

Tissue repair and regeneration with endogenous stem cells

H **a, X Li, W Gao, X Fu, RH Fang, L Zhang… - Nature Reviews …, 2018 - nature.com
In contrast to non-mammalian vertebrates, mammals and humans have limited innate
capacity for the self-regeneration of tissues and organs owing to differences in genetics …

Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs

TH Qazi, DJ Mooney, GN Duda, S Geissler - Biomaterials, 2017 - Elsevier
Mesenchymal stromal cells (MSCs) secrete paracrine factors that play crucial roles during
tissue regeneration. Whether this paracrine function is influenced by the properties of …