Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Advanced drug delivery systems and artificial skin grafts for skin wound healing
Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require
painstakingly long-term treatment with an immense financial burden to healthcare systems …
painstakingly long-term treatment with an immense financial burden to healthcare systems …
[HTML][HTML] Bioactive hydrogels for bone regeneration
X Bai, M Gao, S Syed, J Zhuang, X Xu, XQ Zhang - Bioactive materials, 2018 - Elsevier
Bone self-healing is limited and generally requires external intervention to augment bone
repair and regeneration. While traditional methods for repairing bone defects such as …
repair and regeneration. While traditional methods for repairing bone defects such as …
Shear-thinning and self-healing hydrogels as injectable therapeutics and for 3D-printing
The design of injectable hydrogel systems addresses the growing demand for minimally
invasive approaches for local and sustained delivery of therapeutics. We developed a class …
invasive approaches for local and sustained delivery of therapeutics. We developed a class …
Effects of mesenchymal stem cell‐derived paracrine signals and their delivery strategies
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …
tissue regeneration and remodeling due to their potent bioactivity, which includes …
Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration
Y Cao, J Tan, H Zhao, T Deng, Y Hu, J Zeng… - Nature …, 2022 - nature.com
Transplantation of mesenchymal stem cells (MSCs) holds promise to repair severe traumatic
injuries. However, current transplantation practices limit the potential of this technique, either …
injuries. However, current transplantation practices limit the potential of this technique, either …
A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing
The injectable hydrogel with desirable biocompatibility and tunable properties can improve
the efficacy of stem cell-based therapy. However, the development of injectable hydrogel …
the efficacy of stem cell-based therapy. However, the development of injectable hydrogel …
Injectable hydrogels for cardiac tissue engineering
In light of the limited efficacy of current treatments for cardiac regeneration, tissue
engineering approaches have been explored for their potential to provide mechanical …
engineering approaches have been explored for their potential to provide mechanical …
Tissue repair and regeneration with endogenous stem cells
In contrast to non-mammalian vertebrates, mammals and humans have limited innate
capacity for the self-regeneration of tissues and organs owing to differences in genetics …
capacity for the self-regeneration of tissues and organs owing to differences in genetics …
Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs
Mesenchymal stromal cells (MSCs) secrete paracrine factors that play crucial roles during
tissue regeneration. Whether this paracrine function is influenced by the properties of …
tissue regeneration. Whether this paracrine function is influenced by the properties of …