Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Designing translational antioxidative agents that could scavenge free radicals produced
during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main …

Purpose Cerebral ischemia induces a profound neuro-inflammatory response, but the
underlying molecular mechanisms are poorly understood. Inflammasomes (NLRP1, NLRP3 …

After ischemic stroke, there is a significant burden of cardiovascular complications, both in
the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of …

Ischemia-reperfusion injury is caused by excessive production of reactive oxygen species
(ROS) and inflammation accompanied by ischemic injury symptoms and blood–brain barrier …

Recovery after stroke is a multicellular process encompassing neurons, resident immune
cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has …

Coronary artery disease continues to be a major cause of morbidity and mortality despite
significant advances in risk stratification and management. This has prompted the search for …

The medical burden of stroke extends beyond the brain injury itself and is largely
determined by chronic comorbidities that develop secondarily. We hypothesized that these …