There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Much of our current knowledge about mitochondria has come from studying patients who
have respiratory chain disorders. These disorders comprise a large collection of individually …

Fatty liver disease that develops in the absence of alcohol abuse is recognized increasingly
as a major health burden. This report summarizes the presentations and discussions at a …

Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies in the general population. Both disorders …

Antiretroviral therapy has changed human immunodeficiency virus (HIV) infection from a
near-certainly fatal illness to one that can be managed chronically. More patients are taking …

Oxidative stress is now recognized as accountable for redox regulation involving reactive
oxygen species (ROS) and reactive nitrogen species (RNS). Its role is pivotal for the …

According to the WHO, 38 million individuals were living with human immunodeficiency virus
(HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019 …

The act of breathing depends on coordinated activity of the respiratory muscles to generate
subatmospheric pressure. This action is compromised by disease states affecting …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Mitochondria are known to combine life-supporting functions with participation in apoptosis
by controlling caspase activity. Here, we report that in human blood neutrophils the …