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P4-ATPases as phospholipid flippases—structure, function, and enigmas
JP Andersen, AL Vestergaard, SA Mikkelsen… - Frontiers in …, 2016 - frontiersin.org
P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids
across cell membranes. This generates and maintains membrane lipid asymmetry, a …
across cell membranes. This generates and maintains membrane lipid asymmetry, a …
Phospholipid flippases: building asymmetric membranes and transport vesicles
Phospholipid flippases in the type IV P-type ATPase family (P4-ATPases) are essential
components of the Golgi, plasma membrane and endosomal system that play critical roles in …
components of the Golgi, plasma membrane and endosomal system that play critical roles in …
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
K Segawa, S Kurata, Y Yanagihashi, TR Brummelkamp… - Science, 2014 - science.org
Phospholipids are asymmetrically distributed in the plasma membrane. This asymmetrical
distribution is disrupted during apoptosis, exposing phosphatidylserine (PtdSer) on the cell …
distribution is disrupted during apoptosis, exposing phosphatidylserine (PtdSer) on the cell …
The sheep genome illuminates biology of the rumen and lipid metabolism
Phosphatidylserine exposure in living cells
HW Shin, H Takatsu - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
P4-ATPases, a subfamily of P-type ATPases, translocate cell membrane phospholipids from
the exoplasmic/luminal leaflet to the cytoplasmic leaflet to generate and maintain membrane …
the exoplasmic/luminal leaflet to the cytoplasmic leaflet to generate and maintain membrane …
Mouse models of inherited retinal degeneration with photoreceptor cell loss
GB Collin, N Gogna, B Chang, N Damkham, J Pinkney… - Cells, 2020 - mdpi.com
Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …
[HTML][HTML] Flip** the script: Advances in understanding how and why P4-ATPases flip lipid across membranes
AC Norris, AJ Mansueto, M Jimenez… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract Type IV P-type ATPases (P4-ATPases) are a family of transmembrane enzymes that
translocate lipid substrates from the outer to the inner leaflet of biological membranes and …
translocate lipid substrates from the outer to the inner leaflet of biological membranes and …
Functional and in silico analysis of ATP8A2 and other P4-ATPase variants associated with human genetic diseases
E Matsell, JP Andersen… - Disease Models & …, 2024 - journals.biologists.com
ABSTRACT P4-ATPases flip lipids from the exoplasmic to cytoplasmic leaflet of cell
membranes, a property crucial for many biological processes. Mutations in P4-ATPases are …
membranes, a property crucial for many biological processes. Mutations in P4-ATPases are …
Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane
H Takatsu, G Tanaka, K Segawa, J Suzuki… - Journal of Biological …, 2014 - jbc.org
Type IV P-type ATPases (P4-ATPases) are believed to translocate aminophospholipids from
the exoplasmic to the cytoplasmic leaflets of cellular membranes. The yeast P4-ATPases …
the exoplasmic to the cytoplasmic leaflets of cellular membranes. The yeast P4-ATPases …