The host inflammatory response in cystic fibrosis (CF) lung disease has long been
recognized as a central pathological feature and an important therapeutic target. Indeed …

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

Cystic fibrosis (CF) pathophysiology is hallmarked by excessive inflammation and the
inability to efficiently resolve lung infections, contributing to major morbidity and eventually …

Background Abnormal macrophage function caused by dysfunctional cystic fibrosis
transmembrane conductance regulator (CFTR) is a critical contributor to chronic airway …

Despite the addition of cystic fibrosis transmembrane conductance regulator (CFTR)
modulators to the cystic fibrosis (CF) treatment regimen, patients with CF continue to suffer …

Cystic fibrosis is the most common life-threatening recessively inherited disease in
Caucasians. Due to early provision of care in specialized reference centers and more …

In cystic fibrosis (CF) patients, hyper-inflammation is a key factor in lung destruction and
disease morbidity. We have previously demonstrated that macrophages drive the lung hyper …

Background Macrophage plasticity allows cells to adopt different phenotypes, a property
with important implications in disorders such as cystic fibrosis (CF) and asthma. Objective …

Etiological therapies aim at repairing the underlying cause of cystic fibrosis (CF), which is
the functional defect of the cystic fibrosis transmembrane conductance regulator (CFTR) …

Rationale: Cystic fibrosis (CF) is a common genetic disease caused by mutations of the
cystic fibrosis transmembrane conductance regulator (CFTR) gene. Persistent lung …