Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020
Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications
have the potential to play adjunctive roles in a variety of regenerative medicine treatment …
have the potential to play adjunctive roles in a variety of regenerative medicine treatment …
Interplay between inflammation and thrombosis in cardiovascular pathology
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
Infectious Diseases Society of America Guidelines on the treatment and management of patients with COVID-19 (April 2020)
Background There are many pharmacologic therapies that are being used or considered for
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …
The role of platelets in immune-mediated inflammatory diseases
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
Implications of macrophage polarization in autoimmunity
Macrophages are extremely heterogeneous and plastic cells with an important role not only
in physiological conditions, but also during inflammation (both for initiation and resolution) …
in physiological conditions, but also during inflammation (both for initiation and resolution) …
Platelets can associate with SARS-Cov-2 RNA and are hyperactivated in COVID-19
Rationale: In addition to the overwhelming lung inflammation that prevails in coronavirus
disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of …
disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of …
[HTML][HTML] Platelet secretion: From haemostasis to wound healing and beyond
EM Golebiewska, AW Poole - Blood reviews, 2015 - Elsevier
Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …
[HTML][HTML] Fluvoxamine: a review of its mechanism of action and its role in COVID-19
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …
The multifaceted role of fibrinogen in tissue injury and inflammation
JP Luyendyk, JG Schoenecker… - Blood, The Journal of the …, 2019 - ashpublications.org
The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity.
Perturbations in either system can prompt primary pathological end points of hemorrhage or …
Perturbations in either system can prompt primary pathological end points of hemorrhage or …
International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …
and various drugs in development. Their diversity of structure and function reflects the …