Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids

Y Tian, L Kong, Q Li, Y Wang, Y Wang, Z An… - Natural product …, 2024 - pubs.rsc.org
Covering: up to June 2024 Benzylisoquinoline alkaloids (BIAs) represent a diverse class of
plant specialized metabolites derived from L-tyrosine, exhibiting significant pharmacological …

Elucidation and biosynthesis of tetrahydroisoquinoline alkaloids: Recent advances and prospects

Y Gao, F Li, Z Yuan, Z Luo, Y Rao - Biotechnology Advances, 2025 - Elsevier
Tetrahydroisoquinoline alkaloids (THIAs) are a prominent class of plant-derived compounds
with various important pharmaceutical applications. Considerable progress has been made …

Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids

L Zhang, S Zhang, L Liao, H Tang, W Wang, F Yin… - ACS …, 2023 - ACS Publications
Benzylisoquinoline alkaloids (BIAs) are key plant metabolites that offer significant
pharmacological benefits. While most naturally isolated BIAs are identified as (S) …

Concise and modular chemoenzymatic total synthesis of bisbenzylisoquinoline alkaloids

J Wang, J Zhao, Z Yu, S Wang, F Guo… - Angewandte …, 2024 - Wiley Online Library
The bisbenzylisoquinoline alkaloids (bisBIAs) have attracted tremendous attention from the
synthetic community due to their diverse and intriguing biological activities. Herein, we …

Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast

Q Li, X Jiao, X Li, W Shi, Y Ma, X Tan… - Journal of Integrative …, 2024 - Wiley Online Library
Aporphine alkaloids have diverse pharmacological activities; however, our understanding of
their biosynthesis is relatively limited. Previous studies have classified aporphine alkaloids …

Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia

H Zhang, Y Wu, M Qiu, Y Zheng, L Chen, X Shi, J Yang… - Food Bioscience, 2024 - Elsevier
Sleep duration is one of the eight factors of health in life. High incidence of insomnia and
other sleep disorders cause insufficient sleep. Chronic mild sleep deprivation leads to …

Characterization of two CYP80 enzymes provides insights into aporphine alkaloid skeleton formation in Aristolochia contorta

F Meng, S Zhang, J Su, B Zhu, X Pan, X Qiu… - The Plant …, 2024 - Wiley Online Library
Aporphine alkaloids are a large group of natural compounds with extensive pharmaceutical
application prospects. The biosynthesis of aporphine alkaloids has been paid attentions in …

Characterization and Molecular Engineering of a N-Methyltransferase from Edible Nelumbo nucifera Leaves Involved in Nuciferine Biosynthesis

S Chen, Z Wang, GQ Dong, H Zhao, Y Zhu… - Journal of Agricultural …, 2024 - ACS Publications
Lotus leaf, traditionally used as both edible tea and herbal medicine in Asia, contains
nuciferine, a lipid-lowering and weight-loss compoud. The biosynthetic pathways of …

DFT calculations, molecular docking, binding free energy analysis and cytotoxicity assay of 7, 7-dimethylaporphine alkaloids with methylenedioxy ring in positions 1 …

ADS Branches, JN da Silva, MDL de Oliveira… - Computational and …, 2024 - Elsevier
In this paper, we present a comprehensive characterization of three 7, 7-dimethylaporphine
alkaloids at a molecular quantum mechanical level using Density Functional Theory (DFT) …

Lineage‐Specific CYP80 Expansion and Benzylisoquinoline Alkaloid Diversity in Early‐Diverging Eudicots

Z An, R Gao, S Chen, Y Tian, Q Li, L Tian… - Advanced …, 2024 - Wiley Online Library
Menispermaceae species, as early‐diverging eudicots, can synthesize valuable
benzylisoquinoline alkaloids (BIAs) like bisbenzylisoquinoline alkaloids (bisBIAs) and …