Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
At the beginning of the end and in the middle of the beginning: structure and maintenance of telomeric DNA repeats and interstitial telomeric sequences
AY Aksenova, SM Mirkin - Genes, 2019 - mdpi.com
Tandem DNA repeats derived from the ancestral (TTAGGG) n run were first detected at
chromosome ends of the majority of living organisms, hence the name telomeric DNA …
chromosome ends of the majority of living organisms, hence the name telomeric DNA …
Mammalian DNA replication timing
Immediately following the discovery of the structure of DNA and the semi-conservative
replication of the parental DNA sequence into two new DNA strands, it became apparent …
replication of the parental DNA sequence into two new DNA strands, it became apparent …
Human RIF1-protein phosphatase 1 prevents degradation and breakage of nascent DNA on replication stalling
RIF1 is a multifunctional protein implicated in controlling DNA replication and repair. Here,
we show that human RIF1 protects nascent DNA from over-degradation at stalled replication …
we show that human RIF1 protects nascent DNA from over-degradation at stalled replication …
Rif1-dependent control of replication timing
Successful duplication of the genome requires the accurate replication of billions of base
pairs of DNA within a relatively short time frame. Failure to accurately replicate the genome …
pairs of DNA within a relatively short time frame. Failure to accurately replicate the genome …
Metazoan DNA replication origins
DNA replication starts with the opening of DNA at sites called DNA replication origins. From
the single sequence-specific DNA replication origin of the small Escherichia coli genome, up …
the single sequence-specific DNA replication origin of the small Escherichia coli genome, up …
Genome-wide screens reveal that resveratrol induces replicative stress in human cells
Y Benslimane, T Bertomeu, J Coulombe-Huntington… - Molecular Cell, 2020 - cell.com
Resveratrol is a natural product associated with wide-ranging effects in animal and cellular
models, including lifespan extension. To identify the genetic target of resveratrol in human …
models, including lifespan extension. To identify the genetic target of resveratrol in human …
DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7
L De Jesús-Kim, LJ Friedman, M Lõoke… - Elife, 2021 - elifesciences.org
The committed step of eukaryotic DNA replication occurs when the pairs of Mcm2-7
replicative helicases that license each replication origin are activated. Helicase activation …
replicative helicases that license each replication origin are activated. Helicase activation …
DDK: the outsourced kinase of chromosome maintenance
PJ Gillespie, JJ Blow - Biology, 2022 - mdpi.com
Simple Summary To ensure the maintenance of genetic stability prior to cell division a cell's
complement of chromosomes must be duplicated. This requires not only the replication of …
complement of chromosomes must be duplicated. This requires not only the replication of …
G-quadruplex binding protein Rif1, a key regulator of replication timing
DNA replication is spatially and temporally regulated during S phase to execute efficient and
coordinated duplication of entire genome. Various epigenomic mechanisms operate to …
coordinated duplication of entire genome. Various epigenomic mechanisms operate to …