Glioblastoma (GBM) is the most common high-grade primary malignant brain tumor with an
extremely poor prognosis. Given the poor survival with currently approved treatments for …

Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

Cancer causes the second-highest rate of death world-wide. A major shortcoming inherent
in most of anticancer drugs is their lack of tumor selectivity. Nanodrugs for cancer therapy …

The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …

The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …

The therapeutic application of heat is very effective in cancer treatment. Both hyperthermia,
ie, heating to 39–45° C to induce sensitization to radiotherapy and chemotherapy, and …

Abstract High Intensity Focused Ultrasound (HIFU) is an emerging and increasingly useful
modality in the treatment of cancer and other diseases. Although traditional use of …

Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-
brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to …

Purpose: The blood–brain barrier (BBB) limits the efficacy of drug therapies for glioblastoma
(GBM). Preclinical data indicate that low-intensity pulsed ultrasound (LIPU) can transiently …

Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …