Modulation of cellular processes by histone and non-histone protein acetylation
M Shvedunova, A Akhtar - Nature reviews Molecular cell biology, 2022 - nature.com
Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
[HTML][HTML] Chromatin modifications and their function
T Kouzarides - Cell, 2007 - cell.com
The surface of nucleosomes is studded with a multiplicity of modifications. At least eight
different classes have been characterized to date and many different sites have been …
different classes have been characterized to date and many different sites have been …
The interplay of histone modifications–writers that read
Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
Acetylation of proteins on lysine residues is a dynamic posttranslational modification that is
known to play a key role in regulating transcription and other DNA-dependent nuclear …
known to play a key role in regulating transcription and other DNA-dependent nuclear …
Covalent histone modifications—miswritten, misinterpreted and mis-erased in human cancers
Post-translational modification of histones provides an important regulatory platform for
processes such as gene transcription and DNA damage repair. It has become increasingly …
processes such as gene transcription and DNA damage repair. It has become increasingly …
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
Histones comprise the major protein component of chromatin, the scaffold in which the
eukaryotic genome is packaged, and are subject to many types of post-translational …
eukaryotic genome is packaged, and are subject to many types of post-translational …
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark
AJ Ruthenburg, CD Allis, J Wysocka - Molecular cell, 2007 - cell.com
Cells employ elaborate mechanisms to introduce structural and chemical variation into
chromatin. Here, we focus on one such element of variation: methylation of lysine 4 in …
chromatin. Here, we focus on one such element of variation: methylation of lysine 4 in …
Transcriptional regulation of the Warburg effect in cancer by SIX1
L Li, Y Liang, L Kang, Y Liu, S Gao, S Chen, Y Li… - Cancer cell, 2018 - cell.com
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic
glycolysis are being developed. However, how the Warburg effect is directly regulated is …
glycolysis are being developed. However, how the Warburg effect is directly regulated is …
Lysine acetylation goes global: from epigenetics to metabolism and therapeutics
Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression
Dynamic regulation of diverse nuclear processes is intimately linked to covalent
modifications of chromatin,. Much attention has focused on methylation at lysine 4 of histone …
modifications of chromatin,. Much attention has focused on methylation at lysine 4 of histone …