Rheumatoid arthritis (RA) is an autoimmune disease that severely affects patients' physical
and mental health, leading to chronic synovitis and destruction of bone joints. Although …

Chronic inflammation plays an important role in the development of metabolic diseases.
These include obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated fatty …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with gut microbiota
disequilibrium and regulatory T (Treg)/T helper 17 (Th17) immune imbalance. Stigmasterol …

The Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development
of organ inflammation in systemic lupus erythematosus (SLE). Metabolic pathways can …

The mammalian intestine harbors a remarkable number of microbes and their components
and metabolites, which are fundamental for the instigation and development of the host …

The biguanide metformin is the most commonly used antidiabetic drug. Recent studies show
that metformin not only improves chronic inflammation by improving metabolic parameters …

Summary T helper 17 (Th17) cells play critical roles in inflammatory and autoimmune
diseases. The lineage‐specific transcription factor ROR γt is the key regulator for Th17 cell …

Background Peroxisome proliferator-activated receptor gamma (PPARγ) is an enhancer of
Treg responses, but the mechanisms remain elusive. This study aimed to solve this problem …

With the ageing of the world population, osteoporosis has become a problem affecting
quality of life. According to the traditional view, the causes of osteoporosis mainly include …

Recent studies have shown that on one hand, tumors need to obtain a sufficient energy
supply, and on the other hand they must evade the body's immune surveillance. Because of …