Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great
volume of knowledge in the field has been accumulated. Here we attempted to organize the …

Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …

Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

When people age their mortality rate increases exponentially, following Gompertz's law.
Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses …

Aging is a complex, challenging phenomenon that requires multiple, interdisciplinary
approaches to unravel its puzzles. To assist basic research on aging, we developed the …

Aging at the molecular level is characterized by the progressive accumulation of molecular
damage. The sources of damage act randomly through environmental and metabolically …

Aging affects a myriad of genetic, biochemical, and metabolic processes, and efforts to
understand the underlying molecular basis of aging are often thwarted by the complexity of …

Background Dietary restriction (DR) has been shown to prolong longevity across diverse
taxa, yet the mechanistic relationship between DR and longevity remains unclear …

Although molecular features underlying aging and species maximum lifespan (MLS) have
been comprehensively studied by transcriptome analyses, the actual impact of transcriptome …