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Simulated biological fluids–a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres
E Innes, HHP Yiu, P McLean, W Brown… - Critical Reviews in …, 2021 - Taylor & Francis
The use of simulated biological fluids (SBFs) is a promising in vitro technique to better
understand the release mechanisms and possible in vivo behaviour of materials, including …
understand the release mechanisms and possible in vivo behaviour of materials, including …
Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia
Bioinspired microrobots capable of actively moving in biological fluids have attracted
considerable attention for biomedical applications because of their unique dynamic features …
considerable attention for biomedical applications because of their unique dynamic features …
Drug metabolism in the lungs: opportunities for optimising inhaled medicines
Z Enlo-Scott, E Bäckström, I Mudway… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction The lungs possess many xenobiotic metabolizing enzymes which influence the
pharmacokinetics and safety of inhaled medicines. Anticipating metabolism in the lungs …
pharmacokinetics and safety of inhaled medicines. Anticipating metabolism in the lungs …
Effective delivery of the anti-mycobacterial peptide NZX in mesoporous silica nanoparticles
E Tenland, A Pochert, N Krishnan… - PLoS …, 2019 - journals.plos.org
Background Intracellular delivery of antimicrobial agents by nanoparticles, such as
mesoporous silica particles (MSPs), offers an interesting strategy to treat intracellular …
mesoporous silica particles (MSPs), offers an interesting strategy to treat intracellular …
Understanding the role of biomolecular coronas in human exposure to nanomaterials
Nanomaterials (NMs) are increasingly used in medical treatments, electronics, and food
additives. However, nanosafety—the possible adverse effects of NMs on human health—is …
additives. However, nanosafety—the possible adverse effects of NMs on human health—is …
Develo** inhaled drugs for respiratory diseases: A medicinal chemistry perspective
E Pasqua, N Hamblin, C Edwards, C Baker-Glenn… - Drug Discovery …, 2022 - Elsevier
Despite the devastating impact of many lung diseases on human health, there is still a
significant unmet medical need in respiratory diseases, for which inhaled delivery …
significant unmet medical need in respiratory diseases, for which inhaled delivery …
Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages
L Selley, L Schuster, H Marbach, T Forsthuber… - Metallomics, 2020 - academic.oup.com
Studies have emphasised the importance of combustion-derived particles in eliciting
adverse health effects, especially those produced by diesel vehicles. In contrast, few …
adverse health effects, especially those produced by diesel vehicles. In contrast, few …
Implications of the coffee-ring effect on virus infectivity
The factors contributing to the survival of enveloped viruses (eg, influenza and SARS-CoV-
2) on fomite surfaces are of societal interest. The bacteriophage Phi6 is an enveloped viral …
2) on fomite surfaces are of societal interest. The bacteriophage Phi6 is an enveloped viral …
A pathway from porous particle technology toward tailoring aerogels for pulmonary drug administration
T Duong, C López-Iglesias, PK Szewczyk… - … in Bioengineering and …, 2021 - frontiersin.org
Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry
powder inhalers (DPIs) are convenient, portable and environmentally friendly devices …
powder inhalers (DPIs) are convenient, portable and environmentally friendly devices …
Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals
D Thiyagarajan, B Huck, B Nothdurft, M Koch… - Drug delivery and …, 2021 - Springer
Pulmonary delivery of nanocarriers for novel antimycobacterial compounds is challenging
because the aerodynamic properties of nanomaterials are sub-optimal for such purposes …
because the aerodynamic properties of nanomaterials are sub-optimal for such purposes …