Simulated biological fluids–a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres

E Innes, HHP Yiu, P McLean, W Brown… - Critical Reviews in …, 2021 - Taylor & Francis
The use of simulated biological fluids (SBFs) is a promising in vitro technique to better
understand the release mechanisms and possible in vivo behaviour of materials, including …

Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia

F Zhang, J Zhuang, Z Li, H Gong, BEF de Ávila… - Nature materials, 2022 - nature.com
Bioinspired microrobots capable of actively moving in biological fluids have attracted
considerable attention for biomedical applications because of their unique dynamic features …

Drug metabolism in the lungs: opportunities for optimising inhaled medicines

Z Enlo-Scott, E Bäckström, I Mudway… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction The lungs possess many xenobiotic metabolizing enzymes which influence the
pharmacokinetics and safety of inhaled medicines. Anticipating metabolism in the lungs …

Effective delivery of the anti-mycobacterial peptide NZX in mesoporous silica nanoparticles

E Tenland, A Pochert, N Krishnan… - PLoS …, 2019 - journals.plos.org
Background Intracellular delivery of antimicrobial agents by nanoparticles, such as
mesoporous silica particles (MSPs), offers an interesting strategy to treat intracellular …

Understanding the role of biomolecular coronas in human exposure to nanomaterials

MG Soliman, A Martinez-Serra, G Antonello… - Environmental …, 2024 - pubs.rsc.org
Nanomaterials (NMs) are increasingly used in medical treatments, electronics, and food
additives. However, nanosafety—the possible adverse effects of NMs on human health—is …

Develo** inhaled drugs for respiratory diseases: A medicinal chemistry perspective

E Pasqua, N Hamblin, C Edwards, C Baker-Glenn… - Drug Discovery …, 2022 - Elsevier
Despite the devastating impact of many lung diseases on human health, there is still a
significant unmet medical need in respiratory diseases, for which inhaled delivery …

Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages

L Selley, L Schuster, H Marbach, T Forsthuber… - Metallomics, 2020 - academic.oup.com
Studies have emphasised the importance of combustion-derived particles in eliciting
adverse health effects, especially those produced by diesel vehicles. In contrast, few …

Implications of the coffee-ring effect on virus infectivity

Q Huang, W Wang, PJ Vikesland - Langmuir, 2021 - ACS Publications
The factors contributing to the survival of enveloped viruses (eg, influenza and SARS-CoV-
2) on fomite surfaces are of societal interest. The bacteriophage Phi6 is an enveloped viral …

A pathway from porous particle technology toward tailoring aerogels for pulmonary drug administration

T Duong, C López-Iglesias, PK Szewczyk… - … in Bioengineering and …, 2021 - frontiersin.org
Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry
powder inhalers (DPIs) are convenient, portable and environmentally friendly devices …

Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

D Thiyagarajan, B Huck, B Nothdurft, M Koch… - Drug delivery and …, 2021 - Springer
Pulmonary delivery of nanocarriers for novel antimycobacterial compounds is challenging
because the aerodynamic properties of nanomaterials are sub-optimal for such purposes …