Background Neuroinflammation has an important role in the pathophysiology of migraine,
which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight …

The implications of neurogenic inflammation and neuroinflammation in the pathophysiology
of migraine have been clearly demonstrated in preclinical migraine models involving several …

Classical migraine patients experience aura, which is transient neurological deficits
associated with cortical spreading depression (CSD), preceding headache attacks. It is not …

Migraine is a complex, debilitating neurovascular disorder, typically characterized by
recurring, incapacitating attacks of severe headache often accompanied by nausea and …

Background Pain is generally concomitant with an inflammatory reaction at the site where
the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal …

Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes
after spreading depolarization, the neuronal hemichannel pannexin 1 (PANX1) opens and …

The role of neuroinflammation in the pathophysiology of migraines is increasingly being
recognized, and cytokines, which are important endogenous substances involved in …

Objective To review and discuss the literature on the role of cortical structure and function in
migraine. Discussion Structural and functional findings suggest that changes in cortical …

Migraine headaches are highly prevalent, affecting 15% of the population. However, despite
many studies to determine this disease's mechanism and efficient management, its …

Epidemiological estimates indicate that individuals with epilepsy are more likely to
experience headaches, including migraine, than individuals without epilepsy. Headaches …