Eight members of the Herpesviridae family commonly infect humans, and close to 100% of
the adult population is infected with at least one of these. The five that cause the most health …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Human cytomegalovirus (HCMV) infections of immunocompetent hosts are characterized by
a dynamic, life-long interaction in which host immune responses, particularly of T cells …

It is now becoming apparent that the immune system undergoes age‐associated alterations,
which accumulate to produce a progressive deterioration in the ability to respond to …

Inflammation is considered a response set by the tissues in response to injury elicited by
trauma or infection. It is a complex network of molecular and cellular interactions that …

A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious
defence against infection with new or re-emerging pathogens throughout life. In the last third …

The process of maintaining life for the individual is a constant struggle to preserve his/her
integrity. This can come at a price when immunity is involved, namely systemic inflammation …

The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …

Accelerated telomere shortening in lymphocytes has been associated with a variety of
human pathologies, including HIV disease, Down syndrome, and cardiovascular disease …

Abstract Systems-based based approaches have begun to shed light on extrinsic factors that
contribute to immune system variation. Among these, CMV (HHV-5, a β-herpesvirus) …