Viruses that replicate in the human respiratory mucosa without infecting systemically,
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …

Avian influenza virus continues to pose zoonotic, epizootic, and pandemic threats
worldwide, as exemplified by the 2020–23 epizootics of re-emerging H5 genotype avian …

Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To
advance informed vaccine design, it is critical that we understand the cellular dynamics …

In the setting of viral challenge, natural killer (NK) cells play an important role as an early
immune responder against infection. During this response, significant changes in the NK cell …

Influenza virus is the pathogen of influenza (flu) and millions of people suffer from the
infection worldwide, posing a significant health risk. The current influenza vaccines induce …

Animal models are essential for studying disease pathogenesis and to test the efficacy and
safety of new vaccines and therapeutics. For most diseases, there is no single model that …

Background Influenza viruses pose a persistent threat to global public health, necessitating
the development of innovative and broadly effective vaccines. Methods This study focuses …

It is crucial to develop universal inhibitors for viral inhibition due to the rapid mutation of
viruses. Herein, a universal aptamer inhibitor was developed that enabled a single DNA …

A universal vaccine that generally prevents influenza virus infection and/or illness remains
elusive. We have been exploring a novel approach to vaccination involving replication …

Introduction Vaccination is the most effective method to control the prevalence of seasonal
influenza and the most widely used influenza vaccine is the inactivated influenza vaccine …