Metastasis, a critical phase of tumor progression, remains a primary challenge in treating
cancer and a major cause of cancer mortality. Cell-cell communication via extracellular …

Simple Summary Multiple Myeloma (MM) is a hematologic malignancy caused by aberrant
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …

Exosomes regulate cell behavior by binding to and delivering their cargo to target cells;
however, the mechanisms mediating exosome-cell interactions are poorly understood …

The outcomes for the majority of patients with myeloma have improved over recent decades,
driven by treatment advances. However, there is a subset of patients considered to have …

The continuous growing, spreading, and metastasis of tumor cells depend on intercellular
communication within cells resident in a tissue environment. Such communication is …

In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs;
however, pathological fractures frequently occur in PCa patients, and bone resorption is …

The heparan sulfate-degrading enzyme heparanase promotes the progression of many
cancers by driving tumor cell proliferation, metastasis and angiogenesis. Heparanase …

Multiple myeloma (MM) pathogenesis and progression largely rely on the cells and
extracellular factors in the bone marrow (BM) microenvironment. Compelling studies have …

Distant organ metastasis, often termed as organotropic metastasis or metastatic
organotropism, is a fundamental feature of malignant tumours and accounts for most cancer …

The clinical need for effective bone regeneration therapy remains in huge demands.
However, the current “gold standard” treatments of autologous and allogeneic bone grafts …