Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

BACKGROUND During early mammalian brain development, transient neurons and circuits
form the scaffold for the development of neuronal networks. In the immature cerebral cortex …

The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

The development of neural circuits has long-lasting effects on brain function, yet our
understanding of early circuit development in humans remains limited. Here, periodic EEG …

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Here, using further optimized 3D culture that allows highly selective induction and long-term
growth of human ES cell (hESC)-derived cortical neuroepithelium, we demonstrate unique …

The desire to reduce the dependence on curated, labeled datasets and to leverage the vast
quantities of unlabeled data has triggered renewed interest in unsupervised (or self …

Dynamic macrostructural and microstructural changes take place from the mid-fetal stage to
2 years after birth. Delineating structural changes of the brain during early development …

The quest for simplicity in a complex world has occupied thinkers for millennia. How to
conceptualize what humans observe around them and what they wish to design in order to …