For many years, researchers have suggested that abnormalities in circadian rhythms may
underlie the development of mood disorders such as bipolar disorder (BPD), major …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Circadian rhythms and the genes that make up the molecular clock have long been
implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Women are twice as likely as men to develop major depressive disorder (MDD) and are
more prone to recurring episodes. Hence, we tested the hypothesis that the illness may …

For over two decades, theorists have suggested that mania relates to heightened sensitivity
of the behavioral activation system (BAS). In this article, we review a burgeoning empirical …

Research aimed at elucidating the underlying neurobiology and genetics of bipolar disorder,
and factors associated with treatment response, have been limited by a heterogeneous …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Plasticity in the brain is important for learning and memory, and allows us to respond to
changes in the environment. Furthermore, long periods of stress can lead to structural and …

Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence
worldwide. Affected individuals experience recurrent episodes of depression and mania …