Next-generation probes, particles, and proteins for neural interfacing

J Rivnay, H Wang, L Fenno, K Deisseroth… - Science …, 2017‏ - science.org
Bidirectional interfacing with the nervous system enables neuroscience research, diagnosis,
and therapy. This two-way communication allows us to monitor the state of the brain and its …

[HTML][HTML] Challenges and opportunities for large-scale electrophysiology with Neuropixels probes

NA Steinmetz, C Koch, KD Harris… - Current opinion in …, 2018‏ - Elsevier
Electrophysiological methods are the gold standard in neuroscience because they reveal
the activity of individual neurons at high temporal resolution and in arbitrary brain locations …

Revealing neuronal function through microelectrode array recordings

MEJ Obien, K Deligkaris, T Bullmann… - Frontiers in …, 2015‏ - frontiersin.org
Microelectrode arrays and microprobes have been widely utilized to measure neuronal
activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate …

Tools for probing local circuits: high-density silicon probes combined with optogenetics

G Buzsáki, E Stark, A Berényi, D Khodagholy… - Neuron, 2015‏ - cell.com
To understand how function arises from the interactions between neurons, it is necessary to
use methods that allow the monitoring of brain activity at the single-neuron, single-spike …

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

J Müller, M Ballini, P Livi, Y Chen, M Radivojevic… - Lab on a Chip, 2015‏ - pubs.rsc.org
Studies on information processing and learning properties of neuronal networks would
benefit from simultaneous and parallel access to the activity of a large fraction of all neurons …

Spatially expandable fiber-based probes as a multifunctional deep brain interface

S Jiang, DC Patel, J Kim, S Yang, WA Mills III… - Nature …, 2020‏ - nature.com
Understanding the cytoarchitecture and wiring of the brain requires improved methods to
record and stimulate large groups of neurons with cellular specificity. This requires …

A 0.0046-mm2 Two-Step Incremental Delta–Sigma Analog-to-Digital Converter Neuronal Recording Front End With 120-mVpp Offset Compensation

D Wendler, D De Dorigo, M Amayreh… - IEEE Journal of Solid …, 2022‏ - ieeexplore.ieee.org
This article presents a recording front end for high-density CMOS neuronal probes with in
situ digitization and electrode offset voltage compensation. The analog front end (AFE) is …

A new high-density (25 electrodes/mm2) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures

HAC Wark, R Sharma, KS Mathews… - Journal of neural …, 2013‏ - iopscience.iop.org
Objective. Among the currently available neural interface devices, there has been a need for
a penetrating electrode array with a high electrode-count and high electrode-density (the …

Fully immersible subcortical neural probes with modular architecture and a delta-sigma ADC integrated under each electrode for parallel readout of 144 recording …

D De Dorigo, C Moranz, H Graf, M Marx… - IEEE Journal of Solid …, 2018‏ - ieeexplore.ieee.org
This paper presents a needle-shaped neural probe which integrates an incremental-ADC
under each electrode in an area of. The modular architecture avoids global routing of noise …

Electrophysiology read-out tools for brain-on-Chip biotechnology

C Forro, D Caron, GN Angotzi, V Gallo, L Berdondini… - Micromachines, 2021‏ - mdpi.com
Brain-on-Chip (BoC) biotechnology is emerging as a promising tool for biomedical and
pharmaceutical research applied to the neurosciences. At the convergence between lab-on …