Molecular mechanisms and targeted therapies including immunotherapy for non-small cell lung cancer

T Nagano, M Tachihara… - Current cancer drug …, 2019 - ingentaconnect.com
Lung cancer is the leading cause of cancer death worldwide. Molecular targeted therapy
has greatly advanced the field of treatment for non-small cell lung cancer (NSCLC), which …

siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery

MJ Gomes, S Martins, B Sarmento - Ageing research reviews, 2015 - Elsevier
As the population ages, brain pathologies such as neurodegenerative diseases and brain
cancer increase their incidence, being the need to find successful treatments of upmost …

MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C

M Liao, L Peng - Cellular & Molecular Biology Letters, 2020 - Springer
Object Non-small lung cancer (NSCLC), with a poor 5-year survival rate (16%), is the major
type of lung cancer. Metastasis has been identified as the main factor that leads to NSCLC …

Paclitaxel and quercetin nanoparticles co-loaded in microspheres to prolong retention time for pulmonary drug delivery

K Liu, W Chen, T Yang, B Wen, D Ding… - International journal …, 2017 - Taylor & Francis
High drug resistance, poor water solubility, short half-life, and low local drug concentration
are obstacles for successful delivery of chemotherapeutic drugs for lung cancer. A new …

Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion

L Li, Q Zhang, K Lian - Cancer Cell International, 2020 - Springer
Abstract Background Circular RNAs (circRNAs), a subgroup of non-coding RNAs, are
recognized as pivotal mediators in various types of cancers. CircRNA_0000284 …

LncRNA MALAT1 accelerates non‐small cell lung cancer progression via regulating miR‐185‐5p/MDM4 axis

D Wang, S Zhang, M Zhao, F Chen - Cancer medicine, 2020 - Wiley Online Library
Non‐small cell lung cancer (NSCLC) is the commonest malignancy with high death rate
around the world. LncRNA metastasis‐associated lung adenocarcinoma transcript 1 …

A CBR framework with gradient boosting based feature selection for lung cancer subtype classification

J Ramos-González, D López-Sánchez… - Computers in biology …, 2017 - Elsevier
Molecular subtype classification represents a challenging field in lung cancer diagnosis.
Although different methods have been proposed for biomarker selection, efficient …

[HTML][HTML] ALG3 contributes to the malignancy of non-small cell lung cancer and is negatively regulated by MiR-98-5p

S Ke, H Qiu, JM Chen, W Shi, C Han, Y Gong… - Pathology-Research and …, 2020 - Elsevier
Abstract Objective Alpha-1, 3-mannosyltransferase (ALG3) is an oncoprotein associated
with multiple malignancies. We aimed to investigate the role and potential mechanisms of …

Design, synthesis and biological evaluation of a new series of arylidene indanones as small molecules for targeted therapy of non-small cell lung carcinoma and …

MD Altıntop, A Özdemir, HE Temel… - European Journal of …, 2022 - Elsevier
In an attempt to identify small molecules for targeted therapy of non-small cell lung
carcinoma (NSCLC) and prostate cancer (PCa), new arylidene indanones (1–10) were …

Mad2 Checkpoint Gene Silencing Using Epidermal Growth Factor Receptor-Targeted Chitosan Nanoparticles in Non-Small Cell Lung Cancer Model

AV Nascimento, A Singh, H Bousbaa… - Molecular …, 2014 - ACS Publications
RNA interference has emerged as a powerful strategy in cancer therapy because it allows
silencing of specific genes associated with tumor progression and resistance. Mad2 is an …