Introduction Chronic constipation is highly prevalent, affecting between 10% and 15% of the
population. The Rome IV criteria categorizes disorders of chronic constipation into four …

Pain is one of the most burdensome symptoms in people with cancer, and opioid analgesics
are considered the mainstay of cancer pain management. For this review, the authors …

Background Opioid use for chronic non‐cancer pain (CNCP) is complex. In the absence of
pan‐European guidance on this issue, a position paper was commissioned by the European …

Gastrointestinal (GI) pain—a form of visceral pain—is common in some disorders, such as
irritable bowel syndrome, Crohn's disease and pancreatitis. However, identifying the cause …

The development of small-molecule calcitonin gene-related peptide (CGRP) receptor
antagonists (gepants) and of monoclonal antibodies targeting the CGRP system has been a …

Background The effect of analgesic modalities on short‐term outcomes in acute pancreatitis
remains unknown. However, preclinical models have raised safety concerns regarding …

Magnesium oxide has been widely used as a laxative for many years in East Asia, yet its
prescription has largely been based on empirical knowledge. In recent years, several new …

Background The optimal analgesic strategy for patients with acute pancreatitis (AP) remains
unknown. Objective The present systematic review and meta-analysis aims to compare the …

Opioids such as morphine—acting at the mu opioid receptor—are the mainstay for treatment
of moderate to severe pain and have good efficacy in these indications. However, these …

Daily use of opioid analgesics has significantly increased in recent years due to an
increasing prevalence of conditions associated with chronic pain. Opioid-induced …