The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
Predisposition to cancer in children and adolescents
CP Kratz, MC Jongmans, H Cavé… - The lancet child & …, 2021 - thelancet.com
Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …
become increasingly evident that inherited genetic factors play a substantial causal role …
Diagnostic challenges in patients with inborn errors of immunity with different manifestations of immune dysregulation
K Pieniawska-Śmiech, G Pasternak… - Journal of Clinical …, 2022 - mdpi.com
Inborn errors of immunity (IEI), formerly known as primary immunodeficiency disorders
(PIDs), are inherited disorders caused by damaging germline variants in single genes …
(PIDs), are inherited disorders caused by damaging germline variants in single genes …
Clinical, histopathological and prognostic features of primary cutaneous acral CD8+ T‐cell lymphoma and other dermal CD8+ cutaneous lymphoproliferations …
Background The differential diagnosis of atypical dermal nonepidermotropic CD8+
lymphocytic infiltrates includes a heterogeneous spectrum of lymphoproliferations with …
lymphocytic infiltrates includes a heterogeneous spectrum of lymphoproliferations with …
A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects
Introduction Autosomal recessively inherited lipopolysaccharide-responsive beige-like
anchor (LRBA) protein deficiency was shown to be responsible for different types of inborn …
anchor (LRBA) protein deficiency was shown to be responsible for different types of inborn …
Inborn errors of immunity and cancer
Simple Summary Inborn Errors of Immunity (IEI) are a heterogeneous group of disorders
characterized by a defect in the function of at least one, and often more, components of the …
characterized by a defect in the function of at least one, and often more, components of the …
Hereditary predisposition to hematopoietic neoplasms: when bloodline matters for blood cancers
With the advent of precision genomics, hereditary predisposition to hematopoietic
neoplasms—collectively known as hereditary predisposition syndromes (HPS)—are being …
neoplasms—collectively known as hereditary predisposition syndromes (HPS)—are being …
Lymphadenopathy at the crossroad between immunodeficiency and autoinflammation: An intriguing challenge
G Costagliola, R Consolini - Clinical & Experimental …, 2021 - academic.oup.com
Lymphadenopathies can be part of the clinical spectrum of several primary
immunodeficiencies, including diseases with immune dysregulation and autoinflammatory …
immunodeficiencies, including diseases with immune dysregulation and autoinflammatory …
Genomic crossroads between non-Hodgkin's lymphoma and common variable immunodeficiency
K Guevara-Hoyer, J Fuentes-Antrás… - Frontiers in …, 2022 - frontiersin.org
Common variable immunodeficiency (CVID) represents the largest group of primary
immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and …
immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and …
[HTML][HTML] Loss of DIAPH1 causes SCBMS, combined immunodeficiency, and mitochondrial dysfunction
M Kaustio, N Nayebzadeh, R Hinttala… - Journal of Allergy and …, 2021 - Elsevier
Background Homozygous loss of DIAPH1 results in seizures, cortical blindness, and
microcephaly syndrome (SCBMS). We studied 5 Finnish and 2 Omani patients with loss of …
microcephaly syndrome (SCBMS). We studied 5 Finnish and 2 Omani patients with loss of …