The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

D-amino acid oxidase (DAO) is a flavoenzyme that metabolizes certain D-amino acids,
notably the endogenous N-methyl D-aspartate receptor (NMDAR) co-agonist, D-serine. As …

d-amino acids are increasingly recognized as important signaling molecules in the
mammalian central nervous system. However, the d-stereoisomer of the amino acid with the …

Background: Based on the glutamatergic NMDA receptor hypofunction theory of
schizophrenia, NMDA receptor modulators (NMDARMs) may have therapeutic potential in …

Glial cells are increasingly recognized as active players that profoundly influence neuronal
synaptic transmission by specialized signaling pathways. In particular, astrocytes have been …

Thirst emerges from a range of cellular changes that ultimately motivate an animal to
consume water. Although thirst-responsive neuronal signals have been reported, the full …

Abstract Alzheimer's disease (AD), the main cause of dementia worldwide, is characterized
by a complex and multifactorial etiology. In large part, excitatory neurotransmission in the …

d-Serine is a brain-enriched d-amino acid that works as a transmitter-like molecule by
physiologically activating NMDA receptors. Synthesis of d-serine is carried out by serine …

Amino acids are important components for peptides and proteins and act as signal
transmitters. Only L‐amino acids have been considered necessary in mammals, including …

Accumulating evidence during the last decade established that d-serine is a key signaling
molecule utilized by neurons and astroglia in the mammalian central nervous system. d …