Biological assay has been based on analysis of all individuals collected from sample
populations. Bulked sample analysis (BSA), which works with selected and pooled …

Over the past decade, a series of experimental strategies for mass spectrometry based
quantitative proteomics and corresponding computational methodology for the processing of …

Quantitative proteomics has traditionally been performed by two-dimensional gel
electrophoresis, but recently, mass spectrometric methods based on stable isotope …

The field of proteomics is built on technologies to analyze large numbers of proteins—ideally
the entire proteome—in the same experiment. Mass spectrometry (MS) has been …

Proteomics is the systematic study of the many and diverse properties of proteins in a
parallel manner with the aim of providing detailed descriptions of the structure, function and …

The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription
initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two …

We describe here a strategy for the large-scale identification of N-glycosylated proteins from
a complex biological sample. The approach, termed isotope-coded glycosylation-site …

A new method is presented for quantifying proteomic and metabolomic profile data by liquid
chromatography− mass spectrometry (LC− MS) with electrospray ionization. This …

Coupling large‐scale sequencing projects with the amino acid sequence information that
can be gleaned from tandem mass spectrometry (MS/MS) has made it much easier to …

Shotgun proteomic methods involving isobaric tagging of peptides enable high-throughput
proteomic analysis. iTRAQ reagents allow simultaneous identification and quantitation of …