Mechanisms of BCL-2 family proteins in mitochondrial apoptosis

PE Czabotar, AJ Garcia-Saez - Nature reviews Molecular cell biology, 2023 - nature.com
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

X **ing on epithelial-mesenchymal-transition and cell death
R Bonfiglio, R Sisto, S Casciardi, V Palumbo… - Science of the Total …, 2024 - Elsevier
We investigated the presence of aluminium (Al) in human colon cancer samples and its
potential association with biological processes involved in cancer progression, such as …

Mitochondrial homeostasis in odontoblast: physiology, pathogenesis and targeting strategies

X Meng, H Mao, M Wan, L Lu, Z Chen, L Zhang - Life Sciences, 2024 - Elsevier
Caries and pulpitis remain a major global disease burden and affect the quality of life of
patients. Odontoblasts are key players in the progression of caries and pulpitis, not only …

[HTML][HTML] Promotion of osteoporotic bone healing by a tannic acid modified strontium-doped biomimetic bone lamella with ROS scavenging capacity and pro …

Z Wu, L Fan, C Chen, Y Ma, X Wu, Y Li, Z Hao… - Smart Materials in …, 2023 - Elsevier
The impaired osteogenic ability and excessive accumulation of reactive oxygen species
(ROS) under osteoporosis severely weaken repair performance of biomimetic bone grafts …

[HTML][HTML] The mechanism and experimental verification of Ixeris sonchifolia promoting apoptosis of hepatocellular carcinoma based on network pharmacology: Ixeris …

BJ Liu, YY Guan, LX Qiao, JM Zhang, AJ Li… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ixeris sonchifolia alias Kudiezi, it was named Ixeris
sonchifolia (Bunge) Hance, a synonym for Crepidiastrum sonchifolium (Bunge) Pak & …