In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

The ability to differentiate between highly similar C–H bonds in a given molecule remains a
fundamental challenge in organic chemistry. In particular, the lack of sufficient steric and …

In contrast to the widely explored methods for the asymmetric synthesis of molecules
bearing a single stereocenter or adjacent stereocenters, the concurrent construction of 1, 3 …

The development of new methods for the direct functionalization of unactivated C–H bonds
is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic …

Many chemical methods have been developed to favor a particular product in
transformations of compounds that have two or more reactive sites. We explored a different …

Carbon–carbon bonds, including those between sp 3-hybridized carbon atoms (alkyl–alkyl
bonds), typically comprise much of the framework of organic molecules. In the case of sp 3 …

Asymmetric hydroalkoxylation of alkenes constitutes a redox-neutral and 100% atom-
economical strategy toward enantioenriched oxygenated building blocks from readily …

1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …

Proximity-driven metalation has been extensively exploited to achieve reactivity and
selectivity in carbon–hydrogen (C–H) bond activation. Despite the substantial improvement …

Method B 692 3.7. Selective Trifluoromethylation of Multi-Functional Substrates 693 3.8.
Enantioselective Trifluoromethylation 695 3.8. 1. Aldehydes and Ketones: With Cinchona …