Host–microbe interactions rewire metabolism in a C.elegans model of leucine breakdown deficiency

YU Lee, BW Fox, R Guo, BJ Curtis, J Yu, S Kim… - Nature …, 2024 - nature.com
In humans, defects in leucine catabolism cause a variety of inborn errors in metabolism.
Here, we use Caenorhabditis elegans to investigate the impact of mutations in mccc-1, an …

Vitamin B12 partially rescues embryonic cell migration defects in C. elegans ephrin mutants by improving both propionic acid breakdown and one-carbon cycle …

TH Ganjawala, E Hsiao, P Amom, R Molaei, S Goodwin… - bioRxiv, 2024 - biorxiv.org
Successful cell migration followed by tissue fusion is required for organogenesis in a
number of tissues, many of which are susceptible to gene-environment interactions that can …

A Systems-Level Study of Transcriptional Regulation of C. elegans Metabolism

S Nanda - 2023 - repository.escholarship.umassmed …
Metabolism is controlled to ensure organismal development and homeostasis. Several
mechanisms regulate metabolism, including allosteric control and transcriptional regulation …

The Genome Scale Metabolic Model for Trichuris Muris Gateway to Host Pathogen Interactions and Therapeutic Targets

O Bay - 2024 - search.proquest.com
Trichuris trichiura, the human whipworm, stands as one of the most prevalent soiltransmitted
helminths infecting humans. In laboratories, the closely related mouse whipworm, Trichuris …

[BOOK][B] A Novel Genetic Method to Study D-2-Hydroxyglutarate (D-2HG) Metabolism

PD Okah - 2023 - search.proquest.com
Abstract D-2-hydroxyglutarate (D-2HG) has emerged as a potent oncometabolite that is
capable of significantly altering chromatin architecture and gene expression, reprogramming …

St. Mary's Hospital

CH Jones - British medical journal, 1862 - pmc.ncbi.nlm.nih.gov
Journal.~~~~~~~~~~~~~~~~~~~~~~ think that our daily experience furnishes very consider-
able proof that the commonest inflammation of the skin and naucous membranes are by no …