[HTML][HTML] Exploitation of glycosylation in enveloped virus pathobiology
Y Watanabe, TA Bowden, IA Wilson… - Biochimica et Biophysica …, 2019 - Elsevier
Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …
Broadly neutralizing antibodies to HIV and their role in vaccine design
DR Burton, L Hangartner - Annual review of immunology, 2016 - annualreviews.org
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer
The envelope glycoprotein trimer (Env) on the surface of HIV-1 recognizes CD4+ T cells and
mediates viral entry. During this process, Env undergoes substantial conformational …
mediates viral entry. During this process, Env undergoes substantial conformational …
Antibody responses to envelope glycoproteins in HIV-1 infection
DR Burton, JR Mascola - Nature immunology, 2015 - nature.com
Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups.
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
The isolation of human monoclonal antibodies is providing important insights into the
specificities that underlie broad neutralization of HIV-1 (reviewed in ref.). Here we report a …
specificities that underlie broad neutralization of HIV-1 (reviewed in ref.). Here we report a …
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
HIV-1 neutralizing antibodies induced by native-like envelope trimers
RW Sanders, MJ van Gils, R Derking, D Sok, TJ Ketas… - Science, 2015 - science.org
INTRODUCTION A major goal of HIV-1 vaccine development is to identify immunogens
capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against …
capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against …
Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers
E Falkowska, KM Le, A Ramos, KJ Doores, JH Lee… - Immunity, 2014 - cell.com
Broadly neutralizing HIV antibodies are much sought after (a) to guide vaccine design, both
as templates and as indicators of the authenticity of vaccine candidates,(b) to assist in …
as templates and as indicators of the authenticity of vaccine candidates,(b) to assist in …
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
The HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the
Env-gp41 subunit, is a critical component of the virus-cell entry machinery. Here, we report …
Env-gp41 subunit, is a critical component of the virus-cell entry machinery. Here, we report …