As a metalloproteinase specialized in releasing membrane-tethered proteins, A Disintegrin
and A Metalloproteinase 17 (ADAM17), also known as Tumor necrosis factor-α Converting …

The pathophysiology of hepatic ischemia/reperfusion injury (IRI) includes a number of
complex and diverse mechanisms involving interactions between hepatocytes, Kupffer cells …

Macrophage nuclear factor erythroid 2‐related factor 2 defic... : Hepatology Macrophage nuclear
factor erythroid 2‐related factor 2 deficiency promotes innate immune activation by tissue …

Abstract Background and Aims Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a master
regulator of reactive oxygen species (ROS) and inflammation and has been implicated in …

Background Tumor necrosis factor-α (TNF-α) is a potent proinflammatory cytokine involved
in a variety of disease pathologies, including ischemia/reperfusion (I/R) injuries in …

Steatosis has a low tolerance against ischemia-reperfusion injury (IRI). To prevent IRI in the
steatotic liver, we attempted to elucidate the protective effect of astaxanthin (ASTX) in the …

Tobacco exposure has been linked to neuroinflammation and adaptive/maladaptive
changes in neurotransmitter systems, including in glutamatergic systems. We examined the …

The study aimed to investigate the potential attenuation effect of chitosan in liver
ischemia/reperfusion injury (I/R), and its relevant protective mechanisms. Chitosan (200 …

Aims/hypothesis TNF-α levels are increased in obesity and type 2 diabetes. The regulation
of TNF-α converting enzyme (TACE) and its inhibitor, tissue inhibitor of metalloproteinase 3 …

Remote ischemic preconditioning (RIPC) is known to have a protective effect against hepatic
ischemia-reperfusion (IR) injury in animal models. However, the underlying mechanism of …