Adipogenesis and metabolic health

AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

Myosteatosis in the context of skeletal muscle function deficit: an interdisciplinary workshop at the National Institute on Aging

R Correa-de-Araujo, O Addison, I Miljkovic… - Frontiers in …, 2020 - frontiersin.org
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases
with aging and is recognized to negatively correlate with muscle mass, strength, and mobility …

Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines

J Bilski, P Pierzchalski, M Szczepanik, J Bonior… - Cells, 2022 - mdpi.com
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

[HTML][HTML] Mechanical basis of bone strength: influence of bone material, bone structure and muscle action

NH Hart, S Nimphius, T Rantalainen… - … of musculoskeletal & …, 2017 - ncbi.nlm.nih.gov
This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

[HTML][HTML] Recent issues on body composition imaging for sarcopenia evaluation

K Lee, Y Shin, J Huh, YS Sung, IS Lee… - Korean journal of …, 2019 - synapse.koreamed.org
Recently, sarcopenia has garnered renewed interest. Sarcopenia is a disease characterized
by decreased skeletal muscle mass and strength/function, which can impair the quality of life …

Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: a new paradigm beyond sarcopenia

H Ahn, DW Kim, Y Ko, J Ha, YB Shin, J Lee… - Ageing Research …, 2021 - Elsevier
Myosteatosis, which is excessive fat infiltration in the skeletal muscle, is now considered a
distinct disease from sarcopenia. Advances in imaging technique have made muscle …

Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity

GM Pagnotti, M Styner, G Uzer, VS Patel… - Nature Reviews …, 2019 - nature.com
Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Osteosarcopenia: a narrative review on clinical studies

A Polito, L Barnaba, D Ciarapica, E Azzini - International Journal of …, 2022 - mdpi.com
Osteosarcopenia (OS) is defined by the concurrent presence of osteopenia/osteoporosis
and sarcopenia. The pathogenesis and etiology of OS involve genetic, biochemical …

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

P JafariNasabian, JE Inglis, W Reilly… - Journal of …, 2017 - joe.bioscientifica.com
A wealth of observational studies show that low testosterone is associated with insulin
resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental …

Progressive resistance training for concomitant increases in muscle strength and bone mineral density in older adults: a systematic review and meta-analysis

SJ O'Bryan, C Giuliano, MN Woessner, S Vogrin… - Sports Medicine, 2022 - Springer
Background Older adults experience considerable muscle and bone loss that are closely
interconnected. The efficacy of progressive resistance training programs to concurrently …