Two genes are synthetic lethal if mutation of either alone is compatible with viability but
mutation of both leads to death. So, targeting a gene that is synthetic lethal to a cancer …

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …

Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By develo** a …

The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9
system for genome editing has greatly expanded the toolbox for mammalian genetics …

Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role
in disease etiology remains poorly understood. We recently discovered a potential causal …

The emergence of large gene expression datasets has revealed the need for improved tools
to identify enriched gene categories and visualize enrichment patterns. While gene …

Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In
order to understand whether and how lysosomes alter with age and contribute to lifespan …

Metazoans identify and eliminate bacterial pathogens in microbe-rich environments such as
the intestinal lumen; however, the mechanisms are unclear. Host cells could potentially use …

Stress-response pathways have evolved to maintain cellular homeostasis and to ensure the
survival of organisms under changing environmental conditions. Whereas severe stress is …

Interventions that delay ageing mobilize mechanisms that protect and repair cellular
components,,, but it is unknown how these interventions might slow the functional decline of …