NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
Autophagy in immunity and inflammation
Autophagy is an essential, homeostatic process by which cells break down their own
components. Perhaps the most primordial function of this lysosomal degradation pathway is …
components. Perhaps the most primordial function of this lysosomal degradation pathway is …
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy
We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …
Autophagy in infection, inflammation and immunity
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity.
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …
Map** and analysis of chromatin state dynamics in nine human cell types
Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non …
of regulatory activity. The approach is especially well suited to the characterization of non …
Systematic identification of trans eQTLs as putative drivers of known disease associations
Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta …
overcome this problem, we performed expression quantitative trait locus (eQTL) meta …
HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
The resolution of genome-wide association studies (GWAS) is limited by the linkage
disequilibrium (LD) structure of the population being studied. Selecting the most likely …
disequilibrium (LD) structure of the population being studied. Selecting the most likely …
[HTML][HTML] Molecular mimicry and autoimmunity
Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …
Management strategies and future directions for systemic lupus erythematosus in adults
L Durcan, T O'Dwyer, M Petri - The Lancet, 2019 - thelancet.com
Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
J Bentham, DL Morris, DS Cunninghame Graham… - Nature …, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …