Proton pump inhibitors (PPIs) are known as a class of pharmaceutical agents that target
H+/K+-ATPase, which is located in gastric parietal cells. PPIs are widely used in the …

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …

Accumulating evidence supports the role of PDZ-binding kinase (PBK)/T-lymphokine-
activated killer-cell-originated protein kinase (TOPK) in mitosis and cell-cycle progression of …

Abstract 'Targeted'or 'biological'cancer treatments rely on differential gene expression
between normal tissue and cancer, and genetic changes that render tumour cells especially …

Background Glioblastomas are invasive therapy resistant brain tumors with extremely poor
prognosis. The Glioma initiating cell (GIC) population contributes to therapeutic resistance …

TOPK (T–lymphokine-activated killer cell–originated protein kinase) is highly and frequently
transactivated in various cancer tissues, including lung and triple-negative breast cancers …

Abstract Background Ginsenoside Rh2 (GRh2) is the main bioactive component in American
ginseng, a commonly used herb, and its antitumor activity had been studied in previous …

Anoikis is a form of apoptosis which occurs when anchorage-dependent cells either show
loss of adhesion or inappropriate adhesion. Only a few cancer cells that detach from the …

Although esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers,
there are major bottlenecks in its therapeutic approaches, primarily the identification of …

Background: PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) is a
serine–threonine kinase and overexpressed in various types of cancer by inhibiting the …