Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …

A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the highly pathogenic
and highly transmissible human coronavirus that is the causative agent for the worldwide …

Polymeric fibrin displays unique structural and biomechanical properties that contribute to its
essential role of generating blood clots that stem bleeds. The aim of this review is to discuss …

Background Fibrinogen is the first coagulation protein to reach critical levels during
traumatic haemorrhage. This laboratory study compares paired plasma samples pre-and …

During the last decade, significant progress has been made in understanding thrombus
composition and organization in the setting of acute ischemic stroke (AIS). In particular …

Patients with cirrhosis frequently acquire profound hemostatic alterations, which may affect
thrombus quality and composition—factors that determine the susceptibility to embolization …

Background The widespread use of the antifibrinolytic agent, tranexamic acid (TXA),
interferes with the quantification of fibrinolysis by dynamic laboratory assays such as clot …

Purpose One in four deaths worldwide is due to thromboembolic disease; that is, one in four
people die from blood clots first forming and then breaking off or embolizing. Once broken …