Detection of mismatched human leukocyte antigens by adaptive immune cells is considered
as the main cause of transplant rejection, leading to either T-cell mediated rejection or …

Abstract Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes~ 50%
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …

Genetic modification of porcine donors, combined with optimized immunosuppression, has
been shown to improve outcomes of experimental xenotransplant. However, little is known …

Despite advances in post-transplant management, the long-term survival rate of kidney
grafts and patients has not improved as approximately forty percent of transplants fails within …

Current doctrine is that microvascular inflammation (MVI) triggered by a transplant-recipient
antibody response against alloantigens (antibody-mediated rejection) is the main cause of …

Abstract The Sensitization in Transplantation: Assessment of Risk workgroup is a
collaborative effort of the American Society of Transplantation and the American Society of …

Background Circulating anti-HLA donor-specific antibodies (HLA-DSA) are often absent in
kidney transplant recipients with microvascular inflammation (MVI). Missing self, the inability …

Background Circulating donor-specific anti-HLA antibodies (HLA-DSAs) are often absent in
serum of kidney allograft recipients whose biopsy specimens demonstrate histology of …

Late antibody‐mediated rejection (ABMR) is a cardinal cause of kidney allograft failure,
manifesting as a continuous and, in contrast with early rejection, often clinically silent …

The purpose of the STAR 2019 Working Group was to build on findings from the initial STAR
report to further clarify the expectations, limitations, perceptions, and utility of alloimmune …