Rolling circle amplification (RCA) is an efficient enzymatic isothermal reaction that using
circular probe as a template to generate long tandem single-stranded DNA or RNA products …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

Biochemical methods can reveal stable protein‐protein interactions occurring within cells,
but the ability to observe transient events and to visualize the subcellular localization of …

The term “intracellular complement” has been introduced recently as an umbrella term to
distinguish functions of complement proteins that take place intracellularly, rather than in the …

Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian
cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin …

The essential roles of proliferating cell nuclear antigen (PCNA) as a scaffold protein in DNA
replication and repair are well established, while its cytosolic roles are less explored. Two …

Protein–protein interactions (PPIs) regulate signalling pathways and cell phenotypes, and
the visualization of spatially resolved dynamics of PPIs would thus shed light on the …

Synapse loss strongly correlates with cognitive decline in Alzheimer's disease (AD), but the
underlying mechanisms are poorly understood. Deficient Wnt signaling contributes to …

Proteins are one of the main constituents of living cells. Studying the quantities of proteins
under physiological and pathological conditions can give valuable insights into health …

Fluorescence signal enhancement via isothermal nucleic acid amplification is an important
approach for sensitive imaging of intra-or extracellular nucleic acid or protein biomarkers …