Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal
studies have indicated that allergic diseases occur in a time-based order: from atopic …

An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

Background Atopic dermatitis is the most common chronic inflammatory skin disorder,
affecting up to 20% of children and 10% of adults in industrialized countries. This highly …

Human skin acts as a primary barrier between the body and its environment. Crucial for this
skin barrier function is the lipid matrix in the outermost layer of the skin, the stratum corneum …

Background Previous studies found conflicting results about the commonality of different
atopic dermatitis (AD) signs and symptoms. Objective To determine the prevalences of AD …

Emollients and moisturisers for eczema - van Zuuren, EJ - 2017 | Cochrane Library Skip to
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The epidermis protects human subjects from exogenous stressors and helps to maintain
internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is …

The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the
cause of ichthyosis vulgaris—the most common disorder of keratinization—and also a strong …