Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids
that in mammals require peroxisomes for their biosynthesis. They are major components of …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Drug addiction is a chronic brain disorder leading to complex adaptive changes within the
brain reward circuits that involve several neurotransmitters. One of the neurochemical …

Marijuana is the most commonly used illegal drug, particularly in Western societies. The
discovery of an endogenous cannabinoid system (ECS) highlighted new molecules in …

There are two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs, with
other candidates, such as GPR55, PPARs and vanilloid TRPV1 (VR1) receptors, which are …

Aim Twin studies have shown that cannabis use disorders (abuse/dependence) are highly
heritable. This review aims to:(i) review existing linkage studies of cannabis use disorders …

The potential involvement of the cannabinoid CB 2 receptors (CB 2 r) in the adaptive
responses induced by cocaine was studied in transgenic mice overexpressing the CB 2 r …

Although previously thought of as the peripheral cannabinoid receptor, it is now accepted
that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes …

Cannabinoid receptors type 2 (CB2) represent a target with increasing importance for
neuroimaging due to its upregulation under various pathological conditions. Encouraged by …

Recently, the presence of functional interaction between the opioid and cannabinoid system
has been shown in various pharmacological responses. Although there is an increasing …