The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Disease models are essential for understanding cardiovascular disease pathogenesis and
develo** new therapeutics. The human induced pluripotent stem cell (iPSC) technology …

Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …

The prospect of changing the plasticity of terminally differentiated cells toward pluripotency
has completely altered the outlook for biomedical research. Human-induced pluripotent …

Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …

Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …

Tractable and accurate disease models are essential for understanding disease
pathogenesis and for develo** new therapeutics. As stem cells are capable of self …

The advent of human induced pluripotent stem cell (hiPSC) technology has revitalized the
efforts in the past decade to realize more fully the potential of human embryonic stem cells …

Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening
cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of …