The most prevalent pathological features of many neurodegenerative diseases are the
aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy …

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system
(UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective …

The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of
translation of expanded repeats that results in the synthesis of homopolymeric expansion …

Abstract GRP78 (glucose-regulated protein, 78 kDa) is a key regulator of endoplasmic
reticulum (ER) stress signaling. Cancer cells are highly proliferative and have high demand …

Pancreatic cancer is the fourth most lethal malignancy and is characterized by poor
immunogenicity. Pancreatic cancer cells have various strategies to suppress host immune …

Background Somatic mutations are involved in hepatocellular carcinoma (HCC)
progression, but the genetic mechanism associated to hepatocarcinogenesis remains poorly …

Until recently, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy were
considered to be two independent systems that target proteins for degradation by …

Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality
control system for cellular proteins as it is intricately involved in their synthesis, folding and …

The identification of a hexanucleotide repeat expansion in a non‐coding region of C9orf72
as a major cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis …

Anti-tumor immune responses have been linked to the regulated release of ATP from
apoptotic cancer cells to engage P2 purinergic receptor signaling cascades in nearby …