Polygenic scoring accuracy varies across the genetic ancestry continuum
Polygenic scores (PGSs) have limited portability across different grou**s of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …
example, by genetic ancestries and/or social determinants of health), preventing their …
Genomic selection and use of molecular tools in breeding programs for indigenous and crossbred cattle in develo** countries: Current status and future prospects
Genomic selection (GS) has resulted in rapid rates of genetic gains especially in dairy cattle
in developed countries resulting in a higher proportion of genomically proven young bulls …
in developed countries resulting in a higher proportion of genomically proven young bulls …
AlphaSimR: an R package for breeding program simulations
This paper introduces AlphaSimR, an R package for stochastic simulations of plant and
animal breeding programs. AlphaSimR is a highly flexible software package able to simulate …
animal breeding programs. AlphaSimR is a highly flexible software package able to simulate …
Semi-parametric estimates of population accuracy and bias of predictions of breeding values and future phenotypes using the LR method
Background Cross-validation tools are used increasingly to validate and compare genetic
evaluation methods but analytical properties of cross-validation methods are rarely …
evaluation methods but analytical properties of cross-validation methods are rarely …
Big data and artificial intelligence‐aided crop breeding: Progress and prospects
W Zhu, W Li, H Zhang, L Li - Journal of Integrative Plant Biology, 2024 - Wiley Online Library
The past decade has witnessed rapid developments in gene discovery, biological big data
(BBD), artificial intelligence (AI)‐aided technologies, and molecular breeding. These …
(BBD), artificial intelligence (AI)‐aided technologies, and molecular breeding. These …
Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification
Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic
value at the individual level—has been widely assessed, uncertainty in PRSs remains …
value at the individual level—has been widely assessed, uncertainty in PRSs remains …
AlphaSim: software for breeding program simulation
This paper describes AlphaSim, a software package for simulating plant and animal
breeding programs. AlphaSim enables the simulation of multiple aspects of breeding …
breeding programs. AlphaSim enables the simulation of multiple aspects of breeding …
Predicting the accuracy of genomic predictions
Background Mathematical models are needed for the design of breeding programs using
genomic prediction. While deterministic models for selection on pedigree-based estimates of …
genomic prediction. While deterministic models for selection on pedigree-based estimates of …
Genomic prediction of autotetraploids; influence of relationship matrices, allele dosage, and continuous genoty** calls in phenotype prediction
Estimation of allele dosage, using genomic data, in autopolyploids is challenging and
current methods often result in the misclassification of genotypes. Some progress has been …
current methods often result in the misclassification of genotypes. Some progress has been …
Marker selection in multivariate genomic prediction improves accuracy of low heritability traits
Multivariate analysis using mixed models allows for the exploration of genetic correlations
between traits. Additionally, the transition to a genomic based approach is simplified by …
between traits. Additionally, the transition to a genomic based approach is simplified by …