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Recent progress in cartilage lubrication
W Lin, J Klein - Advanced Materials, 2021 - Wiley Online Library
Healthy articular cartilage, covering the ends of bones in major joints such as hips and
knees, presents the most efficiently‐lubricated surface known in nature, with friction …
knees, presents the most efficiently‐lubricated surface known in nature, with friction …
Salivary gland function, development, and regeneration
Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …
and overall health. Understanding both the unique structure and physiological function of …
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
Progress in intra-articular therapy
Diarthrodial joints are well suited to intra-articular injection, and the local delivery of
therapeutics in this fashion brings several potential advantages to the treatment of a wide …
therapeutics in this fashion brings several potential advantages to the treatment of a wide …
[HTML][HTML] The biology of Lubricin: Near frictionless joint motion
GD Jay, KA Waller - Matrix Biology, 2014 - Elsevier
Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …
Targeting cartilage EGFR pathway for osteoarthritis treatment
Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying
treatments. Previously, we found that mice with cartilage-specific epidermal growth factor …
treatments. Previously, we found that mice with cartilage-specific epidermal growth factor …
BMSC‐Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR‐326 Targeting HDAC3 and STAT1//NF‐κB p65 to …
H Xu, B Xu - Mediators of Inflammation, 2021 - Wiley Online Library
Background. In the past decade, mesenchymal stem cells (MSCs) have been widely used
for the treatment of osteoarthritis (OA), and noncoding RNAs in exosomes may play a major …
for the treatment of osteoarthritis (OA), and noncoding RNAs in exosomes may play a major …
Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity
Osteoarthritis is a degenerative joint disease that causes pain, degradation, and dysfunction.
Excessive canonical Wnt signaling in osteoarthritis contributes to chondrocyte phenotypic …
Excessive canonical Wnt signaling in osteoarthritis contributes to chondrocyte phenotypic …
Articular cartilage repair: current needs, methods and research directions
D Correa, SA Lietman - Seminars in cell & developmental biology, 2017 - Elsevier
Articular cartilage is a highly specialized tissue whose remarkable properties of
deformability, resistance to mechanical loading, and low-friction gliding are essential to joint …
deformability, resistance to mechanical loading, and low-friction gliding are essential to joint …
Mechanical cues: bidirectional reciprocity in the extracellular matrix drives mechano-signalling in articular cartilage
SJ Gilbert, CS Bonnet, EJ Blain - International journal of molecular …, 2021 - mdpi.com
The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …