Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …

In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases
nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and …

Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely
limits their utilization in liver transplantation. The potential mechanism remains unclear …

Sepsis-associated encephalopathy (SAE) is one of the common serious complications in
sepsis, and the pathogenesis of SAE remains unclear. Sirtuin 1 (SIRT1) has been reported …

Type 2 alveolar epithelial cell (AEC2) senescence is crucial to the pathogenesis of
pulmonary fibrosis (PF). The nicotinamide adenine dinucleotide (NAD+)-consuming enzyme …

Deteriorating sleep quality and physical or mental fatigue in older adults leads to decreased
quality of life and increased mortality rates. This study investigated the effects of the time …

Ovarian aging occurs prior to the aging of other organ systems and acts as the pacemaker of
the aging process of multiple organs. As life expectancy has increased, preventing ovarian …

Background Aging is the primary risk factor of most chronic diseases in humans, including
cardiovascular diseases, osteoporosis and neurodegenerative diseases, which extensively …

Disrupted biological function, manifesting through the hallmarks of aging, poses one of the
largest threats to healthspan and risk of disease development, such as metabolic disorders …