Mitochondrial diseases are a heterogeneous group of inherited or acquired devastating
disorders that affect the energy metabolism of the body. Many strategies have been …

Methods A systematic PubMed search up to June 2011 was undertaken to identify
medications with evidence of neuroprotection in pre-clinical studies when given either …

Typical Friedreich ataxia (FRDA) is characterized by progressive ataxia with onset from early
childhood to early adulthood with mean age at onset from 10 to 15 years (range: age two …

While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in
cancer patients, concerns about its adverse effects on patient survival have emerged. A lack …

Friedreich's ataxia (FRDA) is an autosomal recessive inherited disorder characterized by
progressive gait and limb ataxia, dysarthria, areflexia, loss of vibratory and position sense …

Erythropoietin (Epo) has been thought to act exclusively on erythroid progenitor cells. The
identification of Epo receptor (EpoR) in non-haematopoietic cells and tissues including …

The traditional role of iron chelation therapy has been to reduce body iron burden via
chelation of excess metal from organs and fluids and its excretion via biliary-fecal and/or …

Mitochondria are essential for cellular function and viability, serving as central hubs of
metabolism and signaling. They possess various metabolic and quality control mechanisms …

Neonatal brain hypoxic-ischemic injury represents a serious health care and socio-
economical problem since it is one of the most common causes of mortality and morbidity of …

Alzheimer's disease (AD) is a debilitating neurodegenerative disease, characterized by
extracellular deposition of senile plaques, mostly amyloid β-protein (Aβ) and neuronal loss …