Intrinsically disordered proteins (IDPs) do not have a well-defined structure under
physiological conditions, but they have key roles in cell signaling and regulation, and they …

MYC-driven medulloblastomas (MB) are highly aggressive pediatric brain tumors with poor
outcomes, and effective therapies remain limited despite intensive multimodal treatments …

Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …

Simple Summary Nuclear protein 1 (NUPR1) is activated in cellular stress and is expressed
at high levels in cancer cells. Much evidence has been gathered supporting its critical role in …

Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and
regulatory functions. Often associated with human diseases, they constitute drug …

Stress contributes to the development of many human diseases, including cancer. Based on
the source of stress, it can be divided into external stress, such as environmental …

Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1
(NUPR1), we found that it binds to several hundreds of proteins, including proteins involved …

The intracellular environment is crowded with macromolecules, including sugars, proteins
and nucleic acids. In the cytoplasm, crowding effects are capable of excluding up to 40% of …

Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse
cellular processes, and provide potential new drug targets because their dysregulation is …

Intrinsically disordered proteins (IDPs) are ubiquitous in eukaryotes, and they are often
associated with diseases in humans. The protein NUPR1 is a multifunctional IDP involved in …